Formulation Optimization of Isosorbide Mononitrate Sustained-release Tablets by Mixture Design / 中国药房
China Pharmacy
;
(12)2007.
Artículo
en Chino
| WPRIM
| ID: wpr-533065
ABSTRACT
OBJECTIVE:
To evaluate the application of mixture design in the design of formulation.METHODS:
Isosorbide mononitrate (ISMN) was used as model drug,and the formulation of ISMN sustained-release tablet was optimized by the mixture design.The optimized ISMN sustained-release tablets were compared with the ISMN sustained-release tablets in market in respect of the release rate in vitro.RESULTS:
The comparison between the validating value and the target value of the optimized sample showed a similarity factor(f2) of 86.56,and there were no differences between the optimized sample and that in market in respect of the drug release in vitro.CONCLUSION:
The mixture design is applicable for the optimization of formulation and it can be used to predict the drug release in vitro.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
China Pharmacy
Año:
2007
Tipo del documento:
Artículo
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