Studies on Content Assay and Fingerprints of Intravenous Emulsion Containing Garlic Oil / 中国药房
China Pharmacy
;
(12)1991.
Artículo
en Chino
| WPRIM
| ID: wpr-533391
ABSTRACT
OBJECTIVE:
To establish and a method for determination of allicin and the fingerprints of intravenous emulsion containing garlic oil.METHODS:
GC method was applied to determine allicin in preparation and the fingerprints of intravenous emulsion containing garlic oil. The separation was performed on HP-5 (30 m?320 ?m?0.25 ?m) column with the flow rate of 1.0 mL?min-1 and inlet temperature of 250 ℃. The column temperature was 60~220 ℃ and rose by temperature-programmed method with N2 as carrier gas. The temperature of FID detector was 300 ℃ with furan as internal standard.RESULTS:
The linear ranges of allicin were 0.05~2.4 mg?mL-1(r=0.999 8). The average recovery were 102.5% (RSD=0.41%,n=9). There were 17 mutual peaks in the fingerprints of intravenous emulsion containing garlic oil. The RSD of intra-day relative retention time and relative peak area were less than 0.05% and 8% respectively. After preparation setting for 48 h at room temperature, the RSD of relative retention time and relative peak areas were less than 0.08% and 15% respectively. The RSD of them in the replicate test were less than 0.04% and 8%, respectively.CONCLUSION:
The method is accurate, reliable, simple and available for quality control of intravenous emulsion containing garlic oil
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
1991
Tipo del documento:
Artículo
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