Preparation of Lansoprazole Enteric-coated Pellet Capsules / 中国药房
China Pharmacy
; (12)1991.
Article
en Zh
| WPRIM
| ID: wpr-533433
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE:To prepare lansoprazole enteric-coated pellet capsules(LECPC).METHODS:The lansoprazole enteric-coated pellets were prepared using fluid-bed coating technology through blank pellets being coated with main component layer,insulating layer and enteric layer in order.Enteric-coated pellets were encapsulated into hard gelatin capsules to obtain LECPC.Drug-loading rate and drug release in artificial intestinal fluid and artificial gastric fluid of 3 batches were investigated.RESULTS:The prepared pellets assumed complete round shape,lustrous appearance and coating well with mean drug-loading rate above 96%.The release of 3 batches in artificial intestinal fluid within 45 minutes were greater than (94.3?0.76) % while were smaller than (6.2?1.6)% in artificial gastric fluid within 2 hours.CONCLUSION:The prepared capsule is feasible in technology,reproducible and reliable in quality.It represents satisfactory release in vitro and property of resisting acid.
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Índice:
WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Año:
1991
Tipo del documento:
Article