Effect of Fuyuan Capsule on the Expression of HIF-1? Kidney of Sepsis Rats / 中国药房
China Pharmacy
;
(12)2005.
Artículo
en Chino
| WPRIM
| ID: wpr-533895
ABSTRACT
OBJECTIVE:
To explore the effect of Fuyuan capsule on the mRNA expression of HIF-1? in kidney of sepsis rats.METHODS:
Male SD rats were randomly divided into sham group,model group and Fuyuan capsule group (low dose and high dose) with 4 rats in each group. CLP operation was done in Fuyuan capsule groups after four days of intragastric administration. RT-PCR testing was applied to determined the expression of HIF-1a in 3 h,6 h,12 h and 24 h after model induction. The level of IL-6 was measured by ELISA method. Blood of heart was sampled for detection of renal function. HE staining was used to observe pathological change of kidney.RESULTS:
As compared with sham group,the mRNA expression of HIF-1? increased gradually within 3 h and reached peak at 24 h(P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
2005
Tipo del documento:
Artículo
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