Relationship of the Change of RAAS Activity with Plasma Glucose after Long Term Therapy of Hydrochlorothiazide / 中国药房

ABSTRACT

OBJECTIVE:To investigate the relationship between the change of RAAS activity and plasma glucose after one year therapy of hydrochlorothiazide. METHODS:A total of 119 hypertensive patients were enrolled in this study. The activity of RAAS and plasma glucose level were measured at baseline. Patients were given 12.5 mg hydrochlorothiazide once a day for one year. Then the relationship between activity change of RAAS and the level of plasma glucose were analyzed. RESULTS:After one year treatment,the decrease of plasma glucose in PRA elevated group and PRA unelevated group were(-0.26?0.26)mmol?L-1 and(-1.36?0.23)mmol?L-1respectively,and there was statistical significance in difference(P