Preparation of Injectable Thermosensitive Meloxicam Hydrogel / 中国药房

ABSTRACT

OBJECTIVE: To develop a new type of injectable sustained thermosensitive meloxicam hydrogel.METHODS: Injectable thermosensitive meloxicam hydrogel was prepared with chitosan-glycerin-borax as carrier.The influence factors of hydrogel were studied such as preparation temperature,pH value,the ratio of glycerin to chitosan.In vitro release of samples was also evaluated.RESULTS: Optimal preparation condition was as follows preparation temperature was 37 ℃ with pH value of 7.0 and the ratio of glycerin to chitosan was 3 ∶ 10.Mean accumulative release of samples was 76% within 288 h.CONCLUSION: Established method is simple and preparation is characterized with high temperature sensitivity and sustained-release.