Study on Pharmacokinetics of Ferulic Acid in Ordinary Guipi Pills and Ultramicro Guipi Pills in Rabbits / 中国药房

ABSTRACT

OBJECTIVE: To study the pharmacokinetic parameter and the relative bioavailability of ferulic acid in ordinary Guipi pills and ultramicro Guipi pills in rabbit.METHODS: HPLC-MS/MS was used to identify the concentration of ferulic acid in the blood sample.RESULTS: Plasma concentration of ferulic acid in ordinary pills was different from that in ultramicro pills.The main pharmacokinetic parameters of ferulic acid in ordinary pills vs.that in ultramicro pills were as followst1/2a(17.59?2.57) min vs.(23.51?4.49) min;t1/2?(300.91?38.74) min vs.(167.17?45.66) min;tmax (9.61?1.69) min vs.(12.33?2.27) min;Cmax(58.92?8.42) ng?mL-1 vs.(112.35?31.29) ng?mL-1;AUC (5 851.67?895.49) ng?min-1?mL-1 vs.(8 586.13?1 497.62) ng?min-1?mL-1.There were significant difference in Cmax and AUC between ordinary pills and ultramicro pills.CONCLUSION: The application of super fine crushing technique in the preparation of Guipi pills could improve the bioavailability of Guipi pills.