PHARMACOLOGICAL STUDIES OF HEMOSTATIC EFFECT OF LIMONIUM BICOLOR(BGE) O KTZE / 西安交通大学学报(医学版)

ABSTRACT

The decoction of Limonium bicolor (Bge.) O. Ktze (LBK) (15g/kg, corresponding to crude drugs) and the alcoholic extractive fluid of LBK (15g/kg. corresponding to crude drugs) were given orally to two groups of rats two times dailyrespectively. After four days, bleeding time of rats was shortened significantly with no distinet effect on coagulation time. The alcoholic extractive fluid (20g/kg, corresponding to crude drugs) was given orally to rats two times dally. After four days, experimental arterial thrombosis was promoted significantly. Obviously, arterial thrombosis is mainly related to platelet adhesion and aggregation, suggesting that the mechanism of the hemostatic effect of LBK may be related to its promotion of platelet adhesion and aggregation. When the decoction of LBK was given orally to mice, LD_(50) was 58.37 ? 10.77g/kg(p = 0.95).