A HISTOCHEMICAL STUDY ON METABOLISM IN THE WALLS OF AGING RATS' HIPPOCAMPAL VESSELS / 西安交通大学学报(医学版)

ABSTRACT

We investigated five enzymes of three metabolic pathways and an index of utilization of generated adenosine triphosphate of smooth muscular contraction. Five enzymes in the vessel walls were seniquantitatively evaluated in the aging rats(SD), Using histochemical method and bright-field microscopy. Lactate dehydrogenase showed significant reactivity which increased with vessel diameter and age in hippocampus. Succinate dehydrogenase and cytochrome oxidase showed little reactivity in hippocampal vessel in all age groups tested. Glucose-6-phosphate dehydrogenase reaction showed slight to moderate reaction. Myosin ATPase reactivity was high in the hippocampal vessels, arteries and arterioles showed very strong reaction, veins showed strong reaction, capillary showed moderate to strong reaction. And then we discussed the relationship between vascular disease and these enzymes in hippocampus.