THE EFFECT OF HBV-TF ON THE IMMUNOLOGICAL FUNCTION OF THE SAME SPACIES GOATS / 西安交通大学学报(医学版)

ABSTRACT

The goats were injected with hepatitis B virus-transfer factor (HBV-TF), which was made from the immune spleen of the same spacies goats immunized with HBsAg After that, we measured the goats cellular immunity and humoral immunity by cheching up the serum anti-HBs level and lymphocyte transformation assay by ~3H-Thymidine (~3H-TdR) incorporation assay. The experiments showed that HBV-TF has the capacity of passing the specific cellular immunity from immune animals to no immune animals. The animals receiving HBV-TF showed a typical skin delay hypersensitivity to specific antigen and augument the effect of lymphocyte transformation in the presence of HBsAg. HBV-TF can also remove the inhibition of lymphocyte transformation caused by HBsAg, Both HBV-TF and N-TF can increase the number of goats blood leucocytes. However HBV-TF and N-TF have no effect on animal's humoral immunity.