PROTECTION OF ADRIAMYCIN-INDUCED SUBACUTE CARDIOMYOPATHY IN MOUSE BY SELENIUM PRETREATMENT / 西安交通大学学报(医学版)

ABSTRACT

The protective effect of selenium (So) on the subacute cardiomyopathy was investigated in the mouse given a single dose of adriamycin (ADR 17. 5mg/kg ip). Se pretreatment (80?g/kg?10 ip) produced protection against the ADR-induced early myocardial damage associated with increased permcability of cell membranes as evidenced by apparent D- PAS (diastase- periodic acid-Schiff) staining material noted in the sarcolemma. The protective effect of Se could be partially explained as the detoxication of lipid peroxides via the action of enhanced cardiac Se-glutathione peroxidase.