THYROXINE INSUFFICIENCY AND RETARDATION OF BRAIN MYELINATION / 中华内分泌代谢杂志

ABSTRACT

The iodine deficient rats fed on low iodine diet demonstrated hypothyroidism with low T3 and T4, and high TSH. Cholesterol content of whole brain tissues in deficient rats at 20 days of age was significantly lower than that of the control, and cerebroside and lipidprotein also markedly decreased. These changes were even more obvious in cerebellum than in cerebrum. However, there was no difference in cerebroside content between the two groups at 42 days of age. The results indicated that retardation of brain myelination and delay in myelinogenesis might be related to thyroxine insufficiency and change in cerebroside was a reversible process.