THE SERUM UPID, APOLIPOPROTEIN A_1 AND B LEVEL IN PITUITARY DWARFISM / 中华内分泌代谢杂志

ABSTRACT

Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), apolipoprotein A1 (Apo A1) and apolipoprotein B (Apo B) were analyzed in 25 cases of pituitary dwarfism with 30 age-matched healthy children as control. The effect of human growth hormone (hGH) therapy for 3 months on these indices were also observed.As a result, the mean values of TC, TG, LDL-C and Apo B in the patients were significantly higher than those in the control, while the mean Apo A1 value was below that of the control. After a 3-month hGH therapy, the TC, LDL-C and Apo B levels decreased significantly while TG and Apo At levels increased significantly. We concluded that lipid metabolic disorder existed to certain extent in patients with pituitary dwarfism and that growth hormone deficiency ,was the main cause of the disorder.