Role of Pulmonary Alveolar Macrophage in Lung Injury after Burn—Blast Combined Injury / 中华创伤杂志

ABSTRACT

In order to clarify the relationship between PAMs and post—trauma lung injury, the H_2O_2 produced by PAMs and catalase activity of bronchoalveolar lavage fluid (BALF) and lung homogenate were measured at hours 6、12、24、48 and 72 after burn、blast injury and burn—blast combined injury in 128 rats, respectively. After trauma, H_2O_2 produced by PAMs was increased compared with PAMs from control lungs, especially in the combined injury groups. The catalase activity of BALF and lung homogenate decreased. The catalase activity in combined injured lungs was the lowest. The results indicated 1. the activation of PAMs might play a role in post—trauma lung injury 2. the damage of pulmonary antioxidant system after trauma may enhanced the lung injury; 3. the state of PAMs activation and the damage of pulmonary antioxidant system were related to the severity of trauma.