A monoclonal antibody to common acute lymphoblastic leukemia antigen (CALLA) and its expression on several human tumor cell lines
Journal of Korean Medical Science
;
: 147-153, 1992.
Artículo
en Inglés
| WPRIM
| ID: wpr-53613
ABSTRACT
We describe a newly-made murine monoclonal antibody to the common acute lymphoblastic leukemia antigen (CALLA), named SHB-10. The antigen detected by SHB-10 has a molecular weight of about 105 kDa. This antibody is very similar to that of conventional anti-CD10 Ab on indirect flowcytometric analysis using lymphoid malignant cell lines and peripheral lymphocytes of acute lymphoblastic leukemia (ALL) patients. The binding of anti-CD10 to Daudi cell and peripheral lymphocytes of ALL patients is blocked by SHB-10. Thus this monoclonal antibody is thought to detect the CALLA. The distribution of antigen detected by SHB-10 on several cell lines of neuroectodermal tumor and lymphoid malignancy was analysed and a slight difference in their cell surface expression is observed when compared with that by conventional anti-CD10. Further biochemical analysis is now under way for a better characterization of this antigen.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Isotipos de Inmunoglobulinas
/
Células Tumorales Cultivadas
/
Neprilisina
/
Antígenos de Diferenciación
/
Biomarcadores de Tumor
/
Citometría de Flujo
/
Ratones Endogámicos BALB C
/
Anticuerpos Monoclonales
/
Antígenos de Neoplasias
/
Neoplasias
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
1992
Tipo del documento:
Artículo
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