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A monoclonal antibody to common acute lymphoblastic leukemia antigen (CALLA) and its expression on several human tumor cell lines
Journal of Korean Medical Science ; : 147-153, 1992.
Artículo en Inglés | WPRIM | ID: wpr-53613
ABSTRACT
We describe a newly-made murine monoclonal antibody to the common acute lymphoblastic leukemia antigen (CALLA), named SHB-10. The antigen detected by SHB-10 has a molecular weight of about 105 kDa. This antibody is very similar to that of conventional anti-CD10 Ab on indirect flowcytometric analysis using lymphoid malignant cell lines and peripheral lymphocytes of acute lymphoblastic leukemia (ALL) patients. The binding of anti-CD10 to Daudi cell and peripheral lymphocytes of ALL patients is blocked by SHB-10. Thus this monoclonal antibody is thought to detect the CALLA. The distribution of antigen detected by SHB-10 on several cell lines of neuroectodermal tumor and lymphoid malignancy was analysed and a slight difference in their cell surface expression is observed when compared with that by conventional anti-CD10. Further biochemical analysis is now under way for a better characterization of this antigen.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Isotipos de Inmunoglobulinas / Células Tumorales Cultivadas / Neprilisina / Antígenos de Diferenciación / Biomarcadores de Tumor / Citometría de Flujo / Ratones Endogámicos BALB C / Anticuerpos Monoclonales / Antígenos de Neoplasias / Neoplasias Límite: Animales / Humanos Idioma: Inglés Revista: Journal of Korean Medical Science Año: 1992 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Isotipos de Inmunoglobulinas / Células Tumorales Cultivadas / Neprilisina / Antígenos de Diferenciación / Biomarcadores de Tumor / Citometría de Flujo / Ratones Endogámicos BALB C / Anticuerpos Monoclonales / Antígenos de Neoplasias / Neoplasias Límite: Animales / Humanos Idioma: Inglés Revista: Journal of Korean Medical Science Año: 1992 Tipo del documento: Artículo