The increase of 3-nitrotyrosine in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis / 中华神经科杂志
Chinese Journal of Neurology
;
(12)1999.
Artículo
en Chino
| WPRIM
| ID: wpr-536347
ABSTRACT
Objective To compare the concentration of 3-nitrotyrosine and tyrosine and the ratio of 3-nitrotyrosine/tyrosine in the cerebrospinal fluid (CSF) of patients with sporadic amyotrophic lateral sclerosis (SALS) and those with healthy nervous system for definiting the role of free radicals oxidative damage in pathogenesis of SALS. Methods Subjects consisted of 15 patients with SALS and 15 patients with norml nervous system who underwent lumbar anesthesia for surgery. Their CSF was analyzed by using high performance liquid chromatography (HPLC). Results The 3-nitrotyrosine concentration was higher in patients with SALS (228.52?124.30 nmol/L) than that in controls (112.86?47.10 nmol/L) (P
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Neurology
Año:
1999
Tipo del documento:
Artículo
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