Effects of arsenic trioxide on different types of human ovarian cancer cell lines in vitro / 中国癌症杂志
China Oncology
; (12)1998.
Article
en Zh
| WPRIM
| ID: wpr-536613
Biblioteca responsable:
WPRO
ABSTRACT
Purpose:To study the effects of arsenic trioxide on the different types of human ovarian cancer cells growth in vitro.Methods:Methyl thiazolyl tetrazolium (MTT)was used to observe the growth inhibition rates of human ovarian cancer cell lines 3AO,SKOV 3 and TYK cells by various concentration arsenic trioxide at different times; Cell apoptosis percentage and cell cycles phase distribution of 3AO were measured by flow cytometry(FCM) assays; Apoptotic phenotype of SKOV 3 was observed by acridine dying. Results:Arsenic trioxide could inhibit the growth of 3AO?SKOV 3 and TYK effectively, depended on the action time and concentration of the medicine(P0.05). Within a certain range, 3AO cells apoptotic percentage induced by arsenic trioxide were enhanced in concentration- and time-dependent patterns(P
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WPRIM
Idioma:
Zh
Revista:
China Oncology
Año:
1998
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Article