Role of matrix metalloproteinase 1 and 2 expression in the invasion of bladder transitional carcinoma / 中华泌尿外科杂志

ABSTRACT

Objective To investigate the expression level of MMP 1 and MMP 2 in the bladder transitional cell carcinoma (BTCC) and to analyse the location feature of expression and to provide a useful marker for judging the invasion. Methods From March 1998 to December 1999,62 cases of BTCC specimens were collected.The expression level of MMP 1 and MMP 2 of the specimens was detected by in situ hybridization technique. Results MMP 1 and MMP 2 were expressed in a small amount in the normal bladder walls.They were expressed mainly in cytoplasm of tumor cells and stromal cells. The positive rate of MMP 1 mRNA was 43.5%,and had no association with cell grade and TNM stage.The positive rate of MMP 2 mRNA was 59.6%.The expression level closely correlated with the cell grade and TNM stage ( P