Aging attenuates the neuroprotective effect by preconditioning with 3-nitropropionic acid / 中华老年医学杂志
Chinese Journal of Geriatrics
;
(12)2001.
Artículo
en Chino
| WPRIM
| ID: wpr-537553
ABSTRACT
Objective To investigate the effect of aging on neuroprotection by preconditioning with 3-nitropropionic acid (3-NPA) and the relationship between aging and adenosine receptor. Methods Population spike amplitude (PSA) in region CA 1 in hippocampal slices was measured during 15 min hypoxia and 45 min posthypoxic recovery from adult and aged mice, which were pretreated in vivo with a single intraperitoneal injection of 3-NPA (20 mg/kg). Posthypoxic PSA recovery was also observed after perfusion with selective agonist or antagonist of adenosine A 1 and A2a receptors. Results Posthypoxic recovery of PSA increased from 26.1?12.2% in control slices to 92.9?15.3% in pretreated slices from adult (P
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Geriatrics
Año:
2001
Tipo del documento:
Artículo
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