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Comorbid Risk Factors of Persistent Pulmonary Hypertension of the Newborn in Infants with Meconium Aspiration Syndrome
Neonatal Medicine ; : 166-171, 2014.
Artículo en Coreano | WPRIM | ID: wpr-53868
ABSTRACT

PURPOSE:

Persistent pulmonary hypertension (PPHN) is considered an important prognostic factor in meconium aspiration syndrome (MAS). The aim of this study was to determine the comorbid risk factors for PPHN in infants with MAS.

METHODS:

We retrospectively analyzed 60 infants diagnosed with MAS and admitted to the neonatal intensive care unit of the Sanggye Paik Hospital from January 2007 to April 2013. There were 28 infants (47%) with PPHN and 32 infants (53%) without PPHN. Clinical characteristics, laboratory findings within 24 hours after birth, and initial capillary blood gas analysis results were compared between infants with and without PPHN.

RESULTS:

Incidence of PPHN was associated with the severity of MAS (P<0.001). The PPHN group had a greater incidence of hypotension and hypoxic-ischemic encephalopathy within 24 hours of birth compared to the non-PPHN group. The PPHN group also had a lower initial pH. However, there was no significant difference for laboratory findings within 24 hours of birth and initial capillary blood gas analysis. In the multivariate analysis, hypotension within 24 hours of birth (P=0.046, odds ratio 11.494, 95% confidence interval 1.048-125.00) was found to be a significant comorbid factor for PPHN in infants with MAS.

CONCLUSION:

Infants with MAS who develop hypotension within 24 hours of birth should be closely monitored for development of PPHN.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Análisis de los Gases de la Sangre / Capilares / Síndrome de Aspiración de Meconio / Cuidado Intensivo Neonatal / Oportunidad Relativa / Incidencia / Análisis Multivariante / Estudios Retrospectivos / Factores de Riesgo / Hipoxia-Isquemia Encefálica Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos / Lactante / Recién Nacido Idioma: Coreano Revista: Neonatal Medicine Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Análisis de los Gases de la Sangre / Capilares / Síndrome de Aspiración de Meconio / Cuidado Intensivo Neonatal / Oportunidad Relativa / Incidencia / Análisis Multivariante / Estudios Retrospectivos / Factores de Riesgo / Hipoxia-Isquemia Encefálica Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos / Lactante / Recién Nacido Idioma: Coreano Revista: Neonatal Medicine Año: 2014 Tipo del documento: Artículo