Effect of IFN-? on the growth of human cervical cancer transplanted subcutaneously in nude mice / 中国癌症杂志

ABSTRACT

Purpose:To study the effect of interferon-? on the growth of human cervical cancer transplanted subcutaneously in nude mice.Methods:Twenty-eight nude mice transplanted subcutaneously with human cervical cancer were divided into 4 groups control group,positive control group(DDP group),IFN-? low dose group(1.5?10 7 u/kg) and IFN-? high dose group(3.0?10 7 u/kg). Different drugs were used from day 14 after transplantation and all mice were sacrificed after 49 days. The weight of the mice and the volume of tumor were measured. FCM was used for measuring the proportion of cell cycle S+G 2 -M(%) in tumor cells. Results:The growth inhibiting rates in DDP group,IFN-? low dose group,IFN-? high dose group were 92.8%,73.8% and 93.1% respectively. Except for mice in DDP group,there was obvious increase in the weight of mice in other three groups. As for the proportion of S+G 2 -M(%),there was no difference in control group,IFN-? low dose group and IFN-? high dose group. Conclusions:IFN-? can inhibit markedly the growth of transplanted cervical cancer,which is correlated with the IFN-? dose. The mechanism of IFN-? inhibiting cervical cancer was not due to the suppression of cancer cell proliferation.