Establishment of Osteosarcoma Models in Mice / 第二军医大学学报

ABSTRACT

Human osteosarcoma cells (HOS-8603) cultured in vitro were injected into the medullary cavities of femur in 5 8-weeks aged NC nude mice and 5 6-weeks aged NC nude mice and in 7 of these animals human osteosarcoma grew. Osteolytic damage, parostium reaction and mass formation were observed on X-ray film. The pathologic findings in this study were similar to the characteristics of original tumor cells and AKP stain was positive.Anti-osteosarcoma monoclonal antibody labeled with 125I was used to carry out experimental guiding diagnostic study in these animal models with a high specificity.