THE CHANGE OF NA~(+)-K~(+)-ATPase ACTIVITY IN ERYTHROCYTES FROM NIDDM PATIENTS / 重庆医科大学学报

ABSTRACT

Na+-K+-ATPase activity of the erythrocyte plasma membrane in noninsulin-de- pendent diabetes mellitus (NIDDM) was studied together with the red cell deform-ability (RCD) and other influencing factors. Comparing with the normal controls, Na+-K+-ATPase activity, Mg++-ATPase activity, and RCD in diabetics were significantly decreased, and the erythrocyte membrane cholesterol and lipid peroxide, fasting blood glucose, and glycosylated hemoglobin were significantly increased. The change of Na+-K+-ATPase activity was positively correlated with RCD, and inversely correlated with fasting blood glucose, erythrocyte membrane cholesterol, and lipid peroxide. The results suggested that the change of Na+-K+-ATPase activity in erythrocyte may contribute to the alterations of RCD in diabetics