Randomized controlled trial of sodium hyaluronate for degenerative disorders of the knee joint / 西安交通大学学报(医学版)
Article
en Zh
| WPRIM
| ID: wpr-539802
Biblioteca responsable:
WPRO
ABSTRACT
Objective To assess the effect of sodium hyaluromate (HA) on degenerative disorders of the knee joint (KJ). Methods A prospective randomized controlled clinical trial was conducted. The experimental group received injections in the compartments of the involved KJ with 1% HA 20mg, whereas the control group received prednisolone (PS) of 75mg once a week with five injections as one course. One week before and after the treatment , clinical symptoms, amount of interleukin-6 (IL-6) and total protein of synovial fluid were measured and compared. Results Both drugs could relieve the clinical symptoms of KJ degenerative disorders. In HA group, marked improvement rate was 52.78% and failure rate was 2.86%, whereas marked improvement rate was 39.29% and failure rate 17.86% in PS group. The declined levels of IL-6 in synovial fluid were notably greater in HA group than those in PS group. Conclusion Intra-articular injection of HA is effective and safe in treating KJ dgenerative disorders with mild adverse reactions.
Texto completo:
1
Índice:
WPRIM
Tipo de estudio:
Clinical_trials
Idioma:
Zh
Revista:
Journal of Xi'an Jiaotong University(Medical Sciences)
Año:
1981
Tipo del documento:
Article