Effects of different analgesic techniques on blood glucose, insulin and cortisol in post-hysterectomy patients / 西安交通大学学报(医学版)

ABSTRACT

Objective To compare the effects of four different analgesic techniques on hyperglycemia and stress response to abdominal hysterectomy so as to select a more reasonable analgesic model. Methods Forty-eight patients were randomly divided into four groups groupⅠreceived 0.2% ropivacaine+fentanyl 2 ?g/mL+ 0.008% ondansetron for PCEA; groupⅡreceived fentanyl 8 ?g/mL+ 0.008% ondansetron for PCIA; groupⅢ received 0.2% ropivacaince+tramadol 2 mg/mL+0.008% ondansetron for PCEA and groupⅥ received tramadol 8 mg/mL+ 0.008% ondansetron for PCIA. The four groups all included loading dose of 5 mL, bolus of 1mL with lock time of 10 minutes and background 1 mL/h. The level of blood glucose, insulin and cortisol were observed at five points before anesthesia, at 2nd hour, 24th hour, 48th hour and 72th hour after the end of surgery. Results All the four analgesic techniques produced satisfactory pain relieve. Hyperglycemia was inhibited more efficiently in groupⅠand group Ⅲ than in groupⅡ and groupⅥ(P