STUDIES ON THE TERATOGENIC EFFECT OF HYDROXYPIPERAQUINE PHOSPHATE / 第二军医大学学报

ABSTRACT

In this experiment, teratogenic effect of Hydroxypiperaquine Phosphate has been studied in mice.We divided the pregnant mice into five groups (1) normal control' (2) positive control, (the mice were administered 0.3 ml concentrated cod liver oil containing vit A 15)000 IU per day.) (3) the highest dose group of HPQP, (1/3LD50 per mouse per day), (4) medium close group (1/9LD50), (5) lower dose group (1/27 LD50).HPQP was given to the mice on the 9th day to the 14th day of gestation.Dams were killed for the teratological examination on the 18th day.We found that the number of the resorbed and dead fetuses markedly increased in the positive control group.The changes of those fetuses included growth retardation and external abnormalities such as microcephaly, encephalocele.open eyes, small ears, phocomelia, syndactylia, ectrodactyly and gastroschiasis were observed.Besides, the cleft palate and some skeletal alterations such as delayed ossifications of skull bones and dilatant ribs were observed too.We have not found in this experiment any evidences of embryotoxicity in the normal and ail of HPQP groups, The experimental results showed that the drug did not exert teratogenic effect on mice.