ACUTE TOXIC RESPONSE OF METRONIDAZOLE DERIVATIVE IN MICE / 第二军医大学学报

ABSTRACT

Metronidazole derivative (CM) administered intraperitoneally or intravenously could cause a marked dose dependent neurotoxic response.The mean LD50 was 5034 mg/kg in the three batches of CM intraperitoneally administered and their effect was statistically identical, and the mean LD50 was 3186 mg/kg in the three baches of CM intravenously administered and their effect was same although there was a significant difference between 8638 and 8646 batches which was probably due to the individual difference in Sensitivity to intravenous injection.