Effects of Gaseity Formaldehyde Exposure on Performance in Water Labyrinth and Hippocampal Neurotransmitters of Mice / 环境与健康杂志

ABSTRACT

Objective To study the effects of formaldehyde inhalation on spatial learning abilities and hippocampal neurotransmitters levels of mice, and to explore the neurotoxic mechanism. Methods Three groups of male Kunming mice were exposed to different concentrations (0, 1.34 and 4.02 mg/m3) of gaseity formaldehyde, 4 h/day, for 7 consecutive days,and their behavior when they learned to perform a water labyrinth task and hippocampal neurotransmitters levels were tested. Results There was no significant difference was seen in swimming duration among groups. While on days 5 and 7, mice in group of 4.02 mg/m3 formaldehyde exposure made notable more swimming errors (P