Investigation of the expression of vascular endothelial growth factor-C and high risk human papillomavirus in different stages of human cervical lesions / 肿瘤研究与临床

ABSTRACT

Objective To study the pathogenetic role of HPV infection and vascular endothelial growth factor-C in the development of cervical carcinomas. Methods HPV16 DNA was tested in cervical intraepithelial neoplasia(CIN) 11I, cervical carcinomas and norma1 cervical tissue by PCR.and the expression of vascular endothelial growth factor-C protein was examined by immunohistochemistry. Results The expression of VEGF-C became stronger and stronger with the progression of cervical diseases from chronical inflammation to CIN and to invasive carcinoma of cervix uteri, but no expression in normal cervical tissue. There was significant correlation between HR-HPV and VEGF-C expression in CIN and cervical carcinomas(odds ratio are 19.12 and 20.49; 95 % confidence interval are 2.31-157.8 and 3.28-226.09). Conclusions The expression of VEGF-C, maybe a sensitive maker, is closely related to HR-HPV infection.