Overexpression of extracelluar signal regulated protein kinase in the temporal lobe of human drug-resistant epilepsy / 中华神经科杂志
Chinese Journal of Neurology
; (12)2005.
Article
en Zh
| WPRIM
| ID: wpr-544004
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate expression of extracelluar signal regulated protein kinase(ERK)and phosphorylation ERK(p-ERK)in the temporal lobe from patients with DR-TLE so as to explore the possible roles of ERK in the pathogenesis of DR-TLE.Methods Expression of ERK was detected with Western blot and immunohistochemistry in 32 patients with DR-TLE(24 temporal lobe,8 hippocampi),as compared with 12 controls(9 temporal lobe,3 hippocampi).Results ERK and p-ERK expression in DR-TLE was significantly higher(0.2266?0.0613,0.2097?0.0183 and 0.1924?0.0054,respectively)than those of controls(0.1840?0.0023,0.1974?0.0056 and 0.1825?0.0063,respectively,all P
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WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Neurology
Año:
2005
Tipo del documento:
Article