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The effect of L-glutamine on intestinal injury following total hepatic inflow occlusion / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery ; (4)1999.
Artículo en Chino | WPRIM | ID: wpr-544797
ABSTRACT

Objectives:

To explore the effect of L-glutamine(Gln) on intestinal injury following total hepatic inflow occlusion.

Methods:

Male Wistar rats were assigned randomly to three groups(n=40)Group A,sham-operation;Group B,control group,rats were pretreated with 4 ml 0.9% saline intraperitonally twice per day on 5 consecutive days;Group C,rats were pretreated with Gln dissolved in 4 ml 0.9% saline intraperitoneally twice per day on 5 consecutive days.The rats in group B and C underwent total hepatic inflow occlusion for 35min by the pringle' s manoeuvre.Ten rats from each group were randomly sacrificed before occlusion and at 2,4,24h after reperfusion respectively.The levels of MDA,SOD,GSH in intestine tissue were measured.The levels of serum TNF-? and portal vein endotoxin were detected.

Results:

Compared with group A,the levels of GSH and SOD decreased after reperfusion(P

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Current Advances in General Surgery Año: 1999 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Current Advances in General Surgery Año: 1999 Tipo del documento: Artículo