Pretreatment of normal responders in fresh in vitro fertilization cycles: A comparison of transdermal estradiol and oral contraceptive pills / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
;
: 228-232, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-54498
ABSTRACT
OBJECTIVE:
The aim of this study was to investigate the impact of pretreatment with transdermal estradiol (E₂) compared to oral contraceptive pills (OCPs) on controlled ovarian stimulation (COS) response in normal responders undergoing fresh in vitro fertilization (IVF)-embryo transfer (ET) cycles.METHODS:
A retrospective cohort study was performed of normal responders undergoing fresh IVF-ET cycles who received pretreatment with transdermal E₂ versus OCPs prior to fresh IVF-ET. The total days of ovarian stimulation, total dosage of gonadotropins, total number of oocytes, and mature oocytes retrieved were noted. Pregnancy outcomes after ET were also recorded.RESULTS:
A total of 2,092 patients met the inclusion criteria 1,057 and 1,035 patients in the transdermal E₂ and OCP groups, respectively. Patients in the OCP group had a longer duration of COS (10.7±1.63 days, p<0.01) than the E₂ group (9.92±1.94 days). Patients in the OCP group also required higher cumulative doses of gonadotropins (2,657.3±1,187.9 IU) than those in the E₂ group (2,550.1±1,270.2 IU, p=0.002). No statistically significant differences were found in the total and mature oocytes retrieved or in the rates of biochemical pregnancy, clinical pregnancy, spontaneous miscarriage, and live birth between the groups.CONCLUSION:
Our findings suggest that compared to OCPs, pretreatment with transdermal E₂ is associated with a shorter duration of ovarian stimulation and lower gonadotropin utilization, without compromising the oocyte yield or pregnancy outcomes in normal-responder patients undergoing fresh IVF.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oocitos
/
Inducción de la Ovulación
/
Superovulación
/
Técnicas In Vitro
/
Resultado del Embarazo
/
Fertilización In Vitro
/
Aborto Espontáneo
/
Estudios Retrospectivos
/
Estudios de Cohortes
/
Anticonceptivos Orales Combinados
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Embarazo
Idioma:
Inglés
Revista:
Clinical and Experimental Reproductive Medicine
Año:
2016
Tipo del documento:
Artículo
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