The effect of Toll like receptor 4 and cytokines on the etiopathogenesis in the rat model with alcoholic liver disease / 中国免疫学杂志
Chinese Journal of Immunology
; (12)2000.
Article
en Zh
| WPRIM
| ID: wpr-545332
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WPRO
ABSTRACT
Objective:To explore the effect of Toll like receptor 4(TLR4) and interleukin 1 belta,6,10 and tumor necrosis ? on the etiopathogenesis in rat model with alcoholic liver disease(ALD).Methods:A rat model of ALD was induced by intragastric alcohol.At the end of 4,8,12 and 16 weeks,liver and serum samples were collected.The levels of interleukin 1 belta,6,10 and tumor necrosis ? in serum were examined.Hematoxylin-eosin,sudan Ⅳ and sirius red staining were performed to obeserve the hepatic pathology.The mRNA expression of TLR4 in liver tissues were examined by reverse transcription polymerase chain raction(RT-PCR) method.Results:With the progress of ALD,the levels of interleukin 1 belta,6 and tumor necrosis ? in serum and the mRNA expression of TLR4 in liver tissues increased significantly(P
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WPRIM
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Zh
Revista:
Chinese Journal of Immunology
Año:
2000
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Article