Effect of Cold Stress on Artery Pressure and Serum Cytokines of Rabbits / 环境与健康杂志

ABSTRACT

Objective To know the effect of cold stress on the artery pressure and the concentration of IL-2, IL-10, IFN-?, TNF-? in the serum of the rabbits. Methods The local white rabbits of China (clean grade) were anesthetized. The mAP (mean artery pressure), mSP (mean systolic pressure), mDP (mean diastolic pressure) and the concentration of IL-2, IL-10, IFN-?, TNF-? were determined at 0 h, 0.25 h, 0.50 h, 0.75 h, 1.00 h, 1.50 h, 2.00 h, 3.00 h, 4.00 h and 6.00 h after cold stress. Results The mAP,mSP and mDP changed undulant with the delay of cold stress,but the whole tendency was descendent. The mAP,mSP and mDP went up to the peak at 1 h,however lower than control. The concentration of IL-2 increased then decreased with the delay of cold stress,the concentration of IL-10 went down then up and the concentration of TNF-?,IFN-? went down gradually. There was a strong correlation between IFN-? and TNF-? (r=0.983 0,P