Role of the Peripheral Vestibular System on Neuroplasticity Induced by Hypergravity Stimulation
Journal of the Korean Balance Society
;
: 213-223, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-54602
ABSTRACT
BACKGROUND AND OBJECTIVES:
Altered environmental gravity, including both hypo- and hypergravity, may result in space adaptation syndrome. To explore the characteristics of this adaptive plasticity, the expression of immediate early gene c-fos mRNA in the vestibular system following an exposure to hypergravity stimulus was determined in rats. MATERIALS ANDMETHOD:
The animals were subjected to 2 G force (two-fold earth's gravity) stimulus for 3 hours, and were examined at post-stimulus hours 0, 2, 6, 12, and 24. Real time reverse transcription-polymerase chain reaction (RT-PCR) was adopted to analyze temporal changes in the expression of c-fos mRNA.RESULTS:
The hypergravity stimulation produced the expression of c-fos mRNA in the vestibular ganglion, medial vestibular nucleus, inferior vestibular nucleus, hippocampus, vestibulocerebellum, and vestibular cortex. The peak expression occurred at hour 6 in the animals hypergravity-stimulated for 3 hours. Bilateral labyrinthectomy significantly attenuated the degree of up-regulation in c-fos mRNA expression. MK-801, an NMDA receptor antagonist, also significantly attenuated the degree of up-regulation in c-fos mRNA expression.CONCLUSION:
These results indicate that the adaptive neuroplasticity in response to an altered gravity occurs in the vestibular-related organs in the central nervous system, in which peripheral vestibular receptors and NMDA receptors play an important role.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plásticos
/
ARN Mensajero
/
Núcleos Vestibulares
/
Regulación hacia Arriba
/
Sistema Nervioso Central
/
Maleato de Dizocilpina
/
N-Metilaspartato
/
Genes fos
/
Receptores de N-Metil-D-Aspartato
/
Mareo por Movimiento Espacial
Límite:
Animales
Idioma:
Coreano
Revista:
Journal of the Korean Balance Society
Año:
2006
Tipo del documento:
Artículo
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