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Role of the Peripheral Vestibular System on Neuroplasticity Induced by Hypergravity Stimulation
Journal of the Korean Balance Society ; : 213-223, 2006.
Artículo en Coreano | WPRIM | ID: wpr-54602
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Altered environmental gravity, including both hypo- and hypergravity, may result in space adaptation syndrome. To explore the characteristics of this adaptive plasticity, the expression of immediate early gene c-fos mRNA in the vestibular system following an exposure to hypergravity stimulus was determined in rats. MATERIALS AND

METHOD:

The animals were subjected to 2 G force (two-fold earth's gravity) stimulus for 3 hours, and were examined at post-stimulus hours 0, 2, 6, 12, and 24. Real time reverse transcription-polymerase chain reaction (RT-PCR) was adopted to analyze temporal changes in the expression of c-fos mRNA.

RESULTS:

The hypergravity stimulation produced the expression of c-fos mRNA in the vestibular ganglion, medial vestibular nucleus, inferior vestibular nucleus, hippocampus, vestibulocerebellum, and vestibular cortex. The peak expression occurred at hour 6 in the animals hypergravity-stimulated for 3 hours. Bilateral labyrinthectomy significantly attenuated the degree of up-regulation in c-fos mRNA expression. MK-801, an NMDA receptor antagonist, also significantly attenuated the degree of up-regulation in c-fos mRNA expression.

CONCLUSION:

These results indicate that the adaptive neuroplasticity in response to an altered gravity occurs in the vestibular-related organs in the central nervous system, in which peripheral vestibular receptors and NMDA receptors play an important role.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plásticos / ARN Mensajero / Núcleos Vestibulares / Regulación hacia Arriba / Sistema Nervioso Central / Maleato de Dizocilpina / N-Metilaspartato / Genes fos / Receptores de N-Metil-D-Aspartato / Mareo por Movimiento Espacial Límite: Animales Idioma: Coreano Revista: Journal of the Korean Balance Society Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plásticos / ARN Mensajero / Núcleos Vestibulares / Regulación hacia Arriba / Sistema Nervioso Central / Maleato de Dizocilpina / N-Metilaspartato / Genes fos / Receptores de N-Metil-D-Aspartato / Mareo por Movimiento Espacial Límite: Animales Idioma: Coreano Revista: Journal of the Korean Balance Society Año: 2006 Tipo del documento: Artículo