Antagonism of Glutathione to Antioxidative Capacity Decrease Induced by Manganese Exposure in Rats / 环境与健康杂志

ABSTRACT

Objective To study the antagonism of glutathione(GSH) to antioxidative capacity decrease induced by manganese exposure in rats.Methods 48 healthy male SD rats were randomly divided into six groups the blank control,GSH control,MnCl2.4H2O(15 mg/kgand 30 mg/kg),15 mg/kgMnCl2.4H2O+1 mmol/kgGSH and 30 mg/kg MnCl2.4H2O+1 mmol/kg GSH,the treatment was conducted through peritoneal injection.The activity of superoxide dismutase(SOD),catalase(CAT) and glutathione peroxidase(GSH-Px)in the serumand the testis were determined bycolorimetric analysis.Results Compared with the blank control group,the activity of SOD,CAT and GSH-Px in the serum and testis in 30 mg/kg groups significantly decreased(P