Research avancement of breast cancer and hypoxia-inducible factor-1 / 中国癌症杂志

ABSTRACT

The hypoxia-inducible factor-1(HIF-1) gene located on the long (q)arm 21-24 of chromosome 14, is composed of HIF-1? and HIF-1? subunits. HIF-1 promotes its target gene HRE to transcribe by binding to the element and then causes a series of responses of the cell to hypoxia. HIF-1 has been found to be overexpressed in breast cancer cell, and the expressions of HIF-1 level were correlated with the prognosis and prediction factors of breast cancer. As a cytokine, HIF-1 will be a new prognosis factor and a new target for the treatment of breast cancer.