Detection of mycoplasma infection in human laryngeal carcinoma / 第二军医大学学报

ABSTRACT

Objective:To detect and analyze the mycoplasma infection in human laryngeal carcinoma and to explore the relationship between the infection with the development,progression and prognosis of laryngeal cancer.Methods: Immunohistochemical methods were employed to detect the mycoplasma infection in 214 specimens of different laryngeal lesions and cervical lymphatic tumors metastasized from laryngeal cancer,including 121 laryngeal cancer specimens,21 laryngeal precancerous specimens,17 vocal cord polypus specimens,14 normal laryngeal tissues adjacent to cancer tissues,9 normal laryngeal tissues opposite to the cancer,and 32 cervical lymphatic tumor specimens metastasized from laryngeal cancer.The infection results were subjected to statistical analysis.Results: The positive rates of mycoplasma 2G10 antibody in laryngeal carcinoma specimens,cervical lymphatic tumor specimens metastasized from laryngeal cancer,laryngeal precancerous specimens,vocal cord polypus specimens,normal laryngeal tissues adjacent to cancer tissues,and normal laryngeal tissues opposite to the cancer were 44.63%(54/121),34.38%(11/32),23.81%(5/21),17.65%(3/17),7.14%(1/14),and 0%(0/9),respectively,with those of laryngeal carcinoma specimens and cervical lymphatic tumor specimens metastasized from laryngeal cancer significantly higher than those of other specimens(P