Effect of prescription Zhuyun-Ⅲ on Th1 and Th2-type cytokines,progesterone and ?-human chorionic gonadotropin in early pregnancy women of threatened abortion / 中国免疫学杂志

ABSTRACT

Objective:To study the clinic effects of Prescription Zhuyun-Ⅲ(ZYⅢ) on early pregnancy women diagnosed as threatened abortion,and its mechanism in immunity and endocrine by determining the changes of serum Th1 and Th2-type cytokines,progesterone(P) and ?-human chorionic gonadotropin(?-HCG).Methods:The treatment group comprised of 30 early pregnancy women diagnosed as threateded abortion as well as deficiency syndrome of deficiency syndrome of Spleen or Kidney diagnosed by TCM,the control group consisted of 20 normal early pregnancy women at similar gestational age.The treatment group was administered with ZYⅢ for 4 weeks.Peripheral blood samples from the above two groups pre-and post-treatment were collected,serum Th1 type cytokine IL-2 and Th2 type cytokine IL-10 were determined by flow-cytometry.Serum P and ?-HCG were determined by ELISA.Results:①The serum IL-2 level and the ratio of IL-2/IL-10 in the treatment group before therapy were significantly higher than the control group(P