Multi-slice CT Perfusion Study on Angiogenesis in Hepatocellular Carcinoma Induced by Hypoxia Inducible Factor-1? / 实用放射学杂志
Journal of Practical Radiology
;
(12)2001.
Artículo
en Chino
| WPRIM
| ID: wpr-546400
ABSTRACT
Objective To study the correlation between multi-slice CT perfusion imaging and angiogenesis in hepatocellular carcinoma(HCC) induced by hypoxia inducible factor-1?(HIF-1?).Methods Multi-slice CT perfusion data were obtained in 34 cases of HCC and 11 cases of hepatic hemangioma identified by operation and pathology.Positive expression of HIF-1? and vascular endothelial growth factor(VEGF) protein of the lesions in all cases and surrounding normal hepatic tissue were investigated with SP immunohistochemistry.Microvessel density(MVD) was determined by anti-CD34 immunostaining.The correlation between multi-slice CT perfusion data and positive expression of HIF-1?,VEGF and CD34 was investigated simultaneously.Results Hepatic arterial perfusion(HAP) and hepatic arterial perfusion index(HAI) in HCC were higher than that of hepatic hemangioma and surrounding normal hepatic tissue(P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Journal of Practical Radiology
Año:
2001
Tipo del documento:
Artículo
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