Effects of Sanjia Yigan Granule on lipid peroxidation in rats with hepatic fibrosis / 西安交通大学学报(医学版)

ABSTRACT

Objective To observe the effects of Sanjia Yigan Granule (S-JG) on hepatic fibrosis and explore its mechanism related to anti-lipid peroxidation in rats. Methods Forty male SD rats were randomly divided into four groups normal group, model group, and compound Salviae Miltiorrhizae (Sm) group and S-JG group. Dimethylnitrosamine was injected intraperitoneally for 4 weeks to induce hepatic fobrosis. At the same time of modeling, Sm and S-JG were given in the corresponding groups. The rats were killed after four weeks. The histomorphylogic structure of the liver tissues was observed under optical microscope; the levels of MDA and SOD in serum were determined by radioimmunoassay. Results Compared with those in normal group, the collagen area in Masson staining and level of serum MDA were inreased obviously, and the level of serum SOD was dereased obviously in model group (P