Effects of sodium ibandronate on titanium particle induced osteolysis / 中国矫形外科杂志

ABSTRACT

[Objective]Titanium particle induced mouse calvarial osteolysis model was used to investigate the effects and mechanisms of sodium ibandronate on osteolysis.[Methods]Twenty-four Kunming species mice were randomly divided into 4 groups,6 in each group.Control group received sham operation.Titanium particle group received 30 mg titanium particle implantation onto the calvariae.One unit sodium ibandronate group and 10 units sodium ibandronate group received 10 mg and 100mg sodium ibandronate ip injection separately on the next day of titanium particles implantation.Ten days later,mice calvariae were harvested for pathology analysis.[Results]In control group osteolysis area was(0.070?0.009)mm2 and osteolysis was not apparent.In titanium particle group osteolysis area(0.369?0.050)mm2 was bigger than that of control group(P