EFFECTS OF GLUCOCORTICOID ON ELECTRICAL ACTIVITIES OF HIPPOCAMPAL NEURONS OF RATS IN VITRO / 第二军医大学学报

ABSTRACT

IntraccUular recording of the rat hippocampal slices was established and used to analyse the effects of glucocorticoid on resting membrane potential as well as input resistance of the cells in CA1 and CA2 of hippocampal slices.The results indicate that the steroid hyperpolarized some of the hippocampal neurons with a tendency of increasing the cells'input resistance within 1-2 min, suggesting that glucocorticoid can influence the function of central neurons in a non-genomic pattern, and the underlying mechanism involves the change of resting membrane potential.