A STUDY OF GASTRIC MUCOSAL HISTOLOGY AND GASTRIC ACID SECRETION AFTER VAGOTOMY / 第二军医大学学报

ABSTRACT

3.5) .Ninteen patients with duodenal ulcer underwent HSV(12) or SV+A (7).BAO and PAO(pentagastrin)decreased by 76.8% and 60% after HSV as compared to 83.4% and 90.4% after SV + A . Geeral clinical postoperative results were appro-ximately the same in the two groups, wih 83.3 % and 86% visick I or II for HSV and SV + A respctively.Results of both animal experiments and clinical investigations showed that HSV caused neither histolo-gical changes in gastric mucosa nor the development or augmentation of gastritis. In contrast bath TV + PP and SV + A induced augmentation of gastritis (especially in the antrum and around the stoma) which might have resulted from reflux of duodenal contents. There was, howver, no relationship between reduction of acicse-cretion and the presence or absence of gatritis and its severity.No reduction of gastric glands were observed. There were no significant changes in size. shape and density of parietal cells postoperatively either. These results provided no histological evidence for post-vagotomy acid secretory reduction.