MODE OF ACTION BETWEEN V-TYPE ORGANOPHOSPHATE POISONS AND ACETYLCHOLINESTERASE / 解放军医学杂志

ABSTRACT

The mode of action of V-type organophosphate poisons on acetylcholinesterase has been studied. It shows that the leaving group of V-type poisons is dialkylamino-ethyl-thio radical,and the phosphonyla-ting site on the enzyme molecule is similar to that of the G-type poison soman, as shown by the competition experiments.