STUDIES ON THE TREATMENT OF SILICOSIS WITH HYDROXYPiPERAQUINE PHOSPHATE / 第二军医大学学报

ABSTRACT

We have synthesized Hydroxypiperaquine Phosphate (HPQP) as a new antimalarial drug in 1971. Studies have shown that the drug has markedly therapeutic effects on experimental silicosis after administration to rats 100mg/kg by oral twice per week and the treatment was performed either in the earlier or later course of silicosis. We tried to treat 663 cases for silicosis with HPQP. Patients took cure up to two years. As a result of therapeutic effect examining by X-ray photograph, it revealed that 153 cases of them were marked improved, a few of cases (about 6.49%) were still in progress, and the remainders were stable as before.This study proved that HPQP can alleviate patients' suffering, prevent or retard the progress of the disease. We, there-fore, recommed the drug to be the choice of good therapeutic medicine for silicosis.