An Observation of Antihistamine & Anti- inflammation Drugs on Pathological Changes of Early Pulmonary Edema in Experimental Respiratory Burns / 第三军医大学学报

ABSTRACT

This article is to report our observation of the therapeutic effect of antihista-mine and anti-inflammation drugs on the early pulmonary edema in respiratory burns. Thirty-two dogs were employed in the experiment and divided into 4 groups: Group Ⅰconsisted of 8 dogs which were inflicted with respiratory tract burns without any treatment and served as the control.Group Ⅱ: 8 animals received H1H2 receptor antagonists of benadryl and cime-tidine after the burns.Group Ⅲ: 8 animals were treated with indomethacin after the burns.Group Ⅳ: 8 animals were treated with dexamethasome after the burns.It was found that under conventional light microscope the interstitial pulmonary edema in GroupⅡ was the mildest and the alveolar edema in both Groups Ⅱ and Ⅲ was milder than in the other two. The difference between Groups Ⅰ and Ⅱ was statistically significant(P