THE ACTIVITY OF ERYTHROCYTE MEMBRANE Na~+ -K~+ ATPase IN PATIENTS OF ESSENTIAL HYPERTENSION TREATED AND UNTREATED WITH LIGUSTICUM WALLICHII HORT / 第二军医大学学报

ABSTRACT

The activity of erythrocyte membrane Na+-K+ATPase was determined from 43 patients with essential hypertension and 10 normotensive controls. Erythrocyte membrane preparation was obtained by washing after hypotonic hemolysis and repeating high speed centrifugal sedimentation. Ouabain was used as a specific inhibitor in Na+-K+ATPase assay. A significantly decreased activity of erythrocyte membrane Na+-K+ATPase was found in these patients of hypertension. Although their clinical manifestations were improved, there were no differences in Na + -K+ATPase activity between treated with Ligusticum Wallichii Hort and untreated groups. The mechanisms involved in these changes were discussed.