THE PREPARATION, PROPERTIES AND CLINICAL USE OF d-KETAMINE HYDRO-CHLORIDE / 第二军医大学学报

ABSTRACT

In this paper, we reported the method and the results for resolution of d-keta-mine hydrochloride with DTA reagent .The optical purity of d-ketamine hydrochlori-de is coordinative with its standard compound.The yield is 35% based on d-ketamine hydrochloride.This compound had been used in 43 patients clinically and obtained good results The dosage was rather smaller and lesser side effects, such as illusion,eyeball quiver and muscular tension. Especially, when the drug is used with pethdine and promet-hazine as complex anesthesia,patients will get better effect. Although the blood pressure and heart rate of patients slightly increased, it is suitable to patients with bleeding and wound.