Effects of BCG, Dexamethasone and Carbon Particles on Invasion of Sporozoites and Development of Exoerythrocytic Forms of Plasmodium yoelii in Rat liver / 第三军医大学学报

ABSTRACT

Wistar rats pretreated with BCG, dexamethasone or carbon particles respectively were inoculated with P. yoelii sporozoites via caudal vein. 42 hours after inoculation, the animals were killed to examine the effects of these 3 agents on the invasion of sporozoites and the development of exoerythrocytic forms (EEF) .It was found that in the carbon group about 30% of the kupffer cells contained the particles, and the density of EEF apparently decreased as compared with that of the control. In the BCG group, a dosage of 6 ? 107 units also caused a marked decrease of EEF density, an,d the parasites were smaller with a higher rate of degenerated forms as compared with those of the control, In the dexamethasone group, however, the EEF density increased markedly up to the level 1.5-2 times higher than that of the control. In addition the EEF were larger and more numerous with vacuoles and some lobulated. The mechanism of these facts were discussed.